UNVEIL Poster 2019.pdf (21.25 MB)
Identification and Characterization of X-linked Hybrid Male Sterility Factors between Drosophila simulans and D. mauritiana
poster
posted on 2020-04-20, 21:30 authored by Rodolfo Villegas, Neal Weldon, Gina Mavhezha, Colin D. MeiklejohnWe demonstrate evidence of at least 4 hybrid male sterility regions within this 4Mb region, including a previously identified HMS factor, OdsH. The D. mauritiana Y chromosome rescues fertility of an OdsH-containing recombinant chromosome reinforcing the hypothesis that OdsH is interacting with a D. simulans Y-linked loci to cause sterility. As the amount of D. mauritiana introgression increases the developmental defects occur earlier in spermatogenesis with B-013 (OdsH-containing sterile recombinant) producing individual mature sperm while 2P6b fails to individualize and even reshape spermatid nuclei.
Funding
Investigating the special role of sex chromosomes in speciation: discovering the molecular identities, functions, and evolutionary histories of X-linked hybrid male sterility genes in Drosophila
National Institute of General Medical Sciences
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