Using Zebrafish to Correlate Hair-Cell Activity with Ototoxin Resistance
posterposted on 22.04.2020 by Daria Lukasz, Katie S. Kindt
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Hair cells, the sensory cells of the auditory system, are acutely susceptible to ototoxins including the live-saving antibiotic neomycin. This work uses larval zebrafish to explore the contribution of hair-cell presynaptic activity to metabolic stress that ultimately influences hair-cell neomycin susceptibility. We find that hair-cell vesicle exocytosis may be the most significant contributor to metabolic stress that may weaken hair cells. This work brings us closer to developing therapies to prevent hearing loss.