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Using Zebrafish to Correlate Hair-Cell Activity with Ototoxin Resistance

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posted on 2020-04-22, 19:57 authored by Daria Lukasz, Katie S. Kindt
Hair cells, the sensory cells of the auditory system, are acutely susceptible to ototoxins including the live-saving antibiotic neomycin. This work uses larval zebrafish to explore the contribution of hair-cell presynaptic activity to metabolic stress that ultimately influences hair-cell neomycin susceptibility. We find that hair-cell vesicle exocytosis may be the most significant contributor to metabolic stress that may weaken hair cells. This work brings us closer to developing therapies to prevent hearing loss.


National Institute on Deafness and Other Communication Disorders (1ZIADC000085-01)


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