Transcriptional profiling in zebrafish using optimized photoswitchable MEK

Patel, Aleena; Yeung, Eyan; McGuire, Sarah; Wu, Andrew; E Toettcher, Jared; Y Shvartsman, Stanislav; D. Burdine, Rebecca

doi:10.6084/m9.figshare.12133263.v1

TAGCposter2020_AleenaPatel.pdf (4.22 MB)

Transcriptional profiling in zebrafish using optimized photoswitchable MEK

poster

posted on 2020-04-20, 23:48 authored by Aleena PatelAleena Patel, Eyan Yeung, Sarah McGuire, Andrew Wu, Jared E Toettcher, Stanislav Y Shvartsman, Rebecca D. Burdine

An optogenetic tool for activating the ERK signaling pathway in vivo in zebrafish is described. The tool is an optimized version of photoswitchable MEK, which we use to investigate the transcriptional effects of ERK activation during germ layer specification.