Transcriptional profiling in zebrafish using optimized photoswitchable MEK
posterposted on 20.04.2020 by Aleena Patel, Eyan Yeung, Sarah McGuire, Andrew Wu, Jared E Toettcher, Stanislav Y Shvartsman, Rebecca D. Burdine
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An optogenetic tool for activating the ERK signaling pathway in vivo in zebrafish is described. The tool is an optimized version of photoswitchable MEK, which we use to investigate the transcriptional effects of ERK activation during germ layer specification.