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The enigmatic DUP240 yeast gene family plays a role in defense against K28 killer toxin
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Using quantitative trait locus (QTL) mapping in Saccharomyces cerevisiae, we pinpointed an uncharacterized gene, YAR028W, which supports resistance to K28 and is the primary gene responsible for the difference in K28 sensitivity between BY and RM strains. Our hypothesis is that DUP240 genes have evolved as a defense mechanism against killer toxins.