Poster_TGAC_4_16_2020_Michael_Lough-Stevens.pdf (609.45 kB)

The absence of the copulatory plug disrupts pregnancy in mice

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posted on 20.04.2020 by Michael Lough-Stevens, Matt Dean

Understanding the biological reasons for implantation failure is important because

pregnancies may fail even when there are no known clinical abnormalities.

• A significant proportion of pregnancy failures may be prevented with a deeper

understanding of the molecular pathways required to initiate and maintain pregnancy.

• We used a mouse model to study pregnancy failure caused by a reproductive defect in

the ejaculate of male mice: the copulatory plug, a solid mass formed from male seminal

fluid in the female mouse’s reproductive tract (see Fig. 1).

• We investigated 1) whether implantation rates go down when females do not receive a

plug and 2) whether progesterone, which is essential for the implantation of fertilizing

eggs in mammals and is upregulated at the time of implantation, is affected by the

presence or absence of a plug.


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