TAGC 2020 Bergstralh.pdf (10.17 MB)
Slogging through Mud: Isoform Expression and Function
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posted on 2020-04-20, 23:11 authored by Nick Lowe, Sifan Yang, Ruiyue Tan, Nick Weeks, Dan BergstralhAbstract: The conserved protein Mud/NuMA/Lin-5 (flies, vertebrates, worms) has long been implicated in the orientation of cell division. Together with Dynein, Mud acts to produce a pulling force that reels astral microtubules, and therefore the metaphase spindle, into alignment. This force is anchored by another conserved factor, Pins/LGN/GPR1-2 (flies, vertebrates, worms), in most cell types examined. We and others have found that multiple isoforms of Mud do not include the Pins-binding domain. Mud is less well-studied outside of spindle orientation, but is implicated in diverse processes, including migration of the oocyte nucleus and spindle cohesion at meiosis II. We are currently investigating the expression and function of Mud isoforms, and in particular whether they participate in Mud function outside of spindle orientation.
Funding
Epithelial Cell Reintegration in Development and Disease
National Institute of General Medical Sciences
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- Animal cell and molecular biology
- Animal developmental and reproductive biology
- Animal physiology - cell
- Biochemistry and cell biology not elsewhere classified
- Cell development, proliferation and death
- Cell and nuclear division
- Evolution of developmental systems
- Genetics not elsewhere classified
- Plant cell and molecular biology
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