2020_TAGC_717C_rkg.pdf (15.11 MB)

Learning from evolution and applying humanized yeast in the quest for new drugs

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poster
posted on 20.04.2020 by Riddhiman K Garge, Hye Ji Cha, Jon M Laurent, Chanjae Lee, Jimmy D Gollihar, Aashiq H Kachroo, John B Wallingford, Edward M Marcotte

This poster describes how our interest in uncovering phenotypic associations across deeply conserved gene modules led us to systematically humanize yeast cells coupled with synthesizing ~30 years of agricultural field studies of pesticide resistance helped us repurpose a novel class of FDA-approved antifungals as vascular disrupting agents.

History

Program Number

717C

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