Poster sessions are particularly prominent at academic conferences. Posters are usually one frame of a powerpoint (or similar) presentation and are represented at full resolution to make them zoomable.
posted on 20.04.2020by Ashutosh Pandey, Beth M. Harvey, Mario F Lopez, Atsuko Ito, Robert S. Haltiwanger, Hamed Jafar-Nejad
We have reported important roles in Drosophila Notch signaling for GlcNAc-fucose-O glycans on three sites: EGF8, 9 and 12. O-fucose monosaccharide on EGF12 (in the absence of Fringe) is essential for Delta-mediated lateral inhibition in embryos. However, wing vein development depends on addition of GlcNAc to EGF8 and 12 by Fringe, with minor contribution from EGF9. Fringe modifications of EGF8 and 12 together prevent Notch from cis-inhibiting Serrate, thereby promoting normal wing margin formation. Our work shows the combinatorial and context-dependent roles of GlcNAc-fucose-O glycans on these sites in Drosophila Notch-ligand interactions.