Dissecting the Genetic Basis of Thermal Tolerance in a Muti-Parental Population of Fruit Flies
posterposted on 20.04.2020 by Patricka Williams-Simon, Enoch Ng'oma, Ronel Ghidey, Elizabeth G. King
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For my research, I use a combination of quantitative genetics and genomics approaches to dissect the genetic basis of thermal tolerance in a multi-parental population of fruit flies, known as the Drosophila Synthetic Population Resource (DSPR). I phenotyped ~40,000 individuals and found that there is a wide range of phenotypic variation in thermal tolerance. I also performed Quantitative Trait Loci (QTL) mapping and found that there are 8 QTLs that influence thermal tolerance in this population. Then, to identify candidate genes I performed RNA-seq and found several possible candidate genes.