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Characterization of metabolic defects across multiple models of ALS

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posted on 20.04.2020 by Hannah Ball, Suvithanandhini Loganathan, Ernesto Manzo, Abigail O'Connor, Gabe Birchak, Daniela C. Zarnescu

Presentation of poster 2014A at TAGC 2020 online. Included is a PDF file of my poster (TAGC.poster.HB.pdf). My work investigates the metabolic defects in ALS using a various Drosophila models. We recently found that glycolysis is upregulated in ALS as a compensatory mechanism to improve ALS phenotypes. This project investigates if increasing glucose availability has a protective effect in multiple ALS fly models. We are also examining PFK localization at the neuromuscular junction to better understand the role it plays at the synapse in ALS. Through this project we hope to better understand the role metabolism has in ALS in the context of TDP-43.

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