A genetic screen to identify the roles of human genes in Drosophila

Presentation of poster 2083A at TAGC 2020 Online. File included is a PDF of the poster (TAGC 2020 Poster - Dongyu Jia Lab.pdf)

In our lab, we conducted a simple screen to identify the roles of hundreds of human genes in Drosophila by observing phenotypic changes of the eye morphology. Virgin female GMR-GAL4 flies were crossed with males containing human genes obtained from Bloomington Drosophila Stock Center. Offspring produced from the crosses with variable eye phenotypes were observed using both a light microscope and a SEM microscope. We found many genes altered the eye morphology, including ones that cause loss of eye bristles, extra eye bristles, ommatidia apoptosis, rough eye, reduction of eye size, and disorganization of ommatidia.