Developing a high content, whole organism behavioral screening platform for plant based compounds
Emily Fryer
Sujay Guha
Lucero Rogel
Angela Xu
Theresa Logan-Garbisch
Sylvia Fechner
Iris Molhoff
Adam Nekimken
Ehsan Rezaei
Lauren A. O'Connell
Shaul Druckmann
Thomas R. Clandinin
Seung Y. Rhee
Miriam B. Goodman
10.6084/m9.figshare.12150642.v1
https://tagc2020.figshare.com/articles/poster/Developing_a_high_content_whole_organism_behavioral_screening_platform_for_plant_based_compounds/12150642
Many high-throughput compound screens have focused on biochemical and cell-based assays, followed by phenotypic assays at the organismal level. However, these widely applied methods limit the identification of new targets. Since nervous system disease biology is complex, targeted biochemical and cell-based assays may not be effective. To address these issues we initiated the Neuroplant Project which engages experts in neuroscience, plant biology, chemistry, and engineering. Our goal is to leverage medicinal plants and animal behavior to identify new chemical and molecular entry points for the treatment of neurological and psychiatric diseases.
2020-04-20 21:35:11
C. elegans
natural compounds
High-Throughput Assay Development
Chemotaxis assay
Behavioral Neuroscience