10.6084/m9.figshare.12149844.v1
Abigail Wukitch
Abigail
Wukitch
Moria Cairns Chambers
Moria Cairns
Chambers
Frank Satriale
Frank
Satriale
The Impact of Multiple Infections within Drosophila melanogaster
TAGC 2020
2020
Drosophila
Host Microbe Interactions
Resistance
Tolerance
Providencia rettgeri
Enterococcus faecalis
Serratia marcescens Sm
Animal Immunology
Immunology
Infectious Diseases
2020-04-20 22:20:44
Poster
https://tagc2020.figshare.com/articles/poster/The_Impact_of_Multiple_Infections_within_Drosophila_melanogaster/12149844
Primary infections in <i>Drosophila melanogaster </i>provide protection against secondary more lethal infections through both increased resistance and increased tolerance. <div><br></div><div>Five day old flies were injected in the abdomen with either Phosphate buffered saline (PBS, control), <i>Enterococcus faecalis</i>, or <i>Serratia marcescens </i>to establish chronic infections. After one week flies were injected in the thorax with a range of doses of <i>Providencia rettgeri</i> to establish lethal infections. Results showed statistically significant protection of flies given <i>E. faecalis</i> or <i>S. marcescens</i> at the primary injection over flies that had only received the control. Survival curves were plotted against bacterial loads and there was both improved resistance, shown by lower loads in doubly infected flies, and improved tolerance, shown by a less steep slope. </div><div><br></div>