%0 Conference Paper %A Garge, Riddhiman K %A Cha, Hye Ji %A Laurent, Jon M %A Lee, Chanjae %A Gollihar, Jimmy D %A Kachroo, Aashiq H %A Wallingford, John B %A M Marcotte, Edward %D 2020 %T Learning from evolution and applying humanized yeast in the quest for new drugs %U https://tagc2020.figshare.com/articles/poster/Learning_from_evolution_and_applying_humanized_yeast_in_the_quest_for_new_drugs/12142479 %R 10.6084/m9.figshare.12142479.v1 %2 https://tagc2020.figshare.com/ndownloader/files/22329702 %K Systems Biology %K Synthetic Biology %K Evolution %K Gene Families %K Humanized Yeast %K Drug Discovery %K Phenologs %K Evolutionary Biology %K Molecular Biology %K Molecular Evolution %K Biochemistry %X

This poster describes how our interest in uncovering phenotypic associations across deeply conserved gene modules led us to systematically humanize yeast cells coupled with synthesizing ~30 years of agricultural field studies of pesticide resistance helped us repurpose a novel class of FDA-approved antifungals as vascular disrupting agents.

%I TAGC 2020