10.6084/m9.figshare.12142203.v1 Hannah Ball Hannah Ball Suvithanandhini Loganathan Suvithanandhini Loganathan Ernesto Manzo Ernesto Manzo Abigail O'Connor Abigail O'Connor Gabe Birchak Gabe Birchak Daniela C. Zarnescu Daniela C. Zarnescu Characterization of metabolic defects across multiple models of ALS TAGC 2020 2020 ALS disease modeling metabolism Animal Cell and Molecular Biology Animal Neurobiology Neuroscience 2020-04-20 23:32:02 Poster https://tagc2020.figshare.com/articles/poster/Characterization_of_metabolic_defects_across_multiple_models_of_ALS/12142203 <p>Presentation of poster 2014A at TAGC 2020 online. Included is a PDF file of my poster (TAGC.poster.HB.pdf). My work investigates the metabolic defects in ALS using a<i> </i>various <i>Drosophila</i> models. We recently found that glycolysis is upregulated in ALS as a compensatory mechanism to improve ALS phenotypes. This project investigates if increasing glucose availability has a protective effect in multiple ALS fly models. We are also examining PFK localization at the neuromuscular junction to better understand the role it plays at the synapse in ALS. Through this project we hope to better understand the role metabolism has in ALS in the context of TDP-43.</p>