10.6084/m9.figshare.12142203.v1
Hannah Ball
Hannah
Ball
Suvithanandhini Loganathan
Suvithanandhini
Loganathan
Ernesto Manzo
Ernesto
Manzo
Abigail O'Connor
Abigail
O'Connor
Gabe Birchak
Gabe
Birchak
Daniela C. Zarnescu
Daniela C.
Zarnescu
Characterization of metabolic defects across multiple models of ALS
TAGC 2020
2020
ALS disease modeling
metabolism
Animal Cell and Molecular Biology
Animal Neurobiology
Neuroscience
2020-04-20 23:32:02
Poster
https://tagc2020.figshare.com/articles/poster/Characterization_of_metabolic_defects_across_multiple_models_of_ALS/12142203
<p>Presentation of poster 2014A at TAGC 2020 online. Included is a PDF file of my poster (TAGC.poster.HB.pdf). My work investigates the metabolic defects in ALS using a<i> </i>various <i>Drosophila</i> models. We recently found that glycolysis is upregulated in ALS as a compensatory mechanism to improve ALS phenotypes. This project investigates if increasing glucose availability has a protective effect in multiple ALS fly models. We are also examining PFK localization at the neuromuscular junction to better understand the role it plays at the synapse in ALS. Through this project we hope to better understand the role metabolism has in ALS in the context of TDP-43.</p>